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FRAGMENT FROM NATURE for this weekend focuses on an article titled ‘Inflammaging: a new immune–metabolic viewpoint for age-related diseases.’ For some decades there has been the growing impression that the common pathway of many chronic diseases is inflammation. This article skillfully summarizes the evidence, https://www.nature.com/articles/s41574-018-0059-4 View in LinkedIn

Keep calm and carry on. Llafranc an the costa brava. Drinks by the Mediterranean while we quietly ignore the various existential threats facing the planet. View in LinkedIn

THE OTHER EXISTENTIAL THREAT. “After launching in November, NASA will test its asteroid deflection technology in September 2022 to see how it impacts the motion of a near-Earth asteroid in space.” (Keep calm and carry on). https://lnkd.in/dew7Qkc9 View in LinkedIn

The lower levels of the huge walls that surround Girona were Roman and clearly quite different in construction technique and material. View in LinkedIn

BOUNDARIES. “It should be noted that formation of antimatter domains can be accompanied by domain walls, which either disappear, as it takes place in, or collapse in black holes, leaving gravitational wave background or primordial black holes, which deserve special study in the context of multimessenger probes of the considered scenarios.” https://www.mdpi.com/2218-1997/7/9/347/htm View in LinkedIn

QUANTUM ENTANGLEMENT. “A wide range of animal species are capable of sensing (and, in some cases, extracting directional information from) the geomagnetic field. A strong candidate hypothesis for explaining these phenomena is the radical pair (RP) mechanism (RPM).” (Via Cryptochromes, which occur also in human cells). https://lnkd.in/dThgXrwZ View in LinkedIn

THE ISSUE OF SELF. “Inflammaging is the by-product of the degeneracy of a few receptors that can sense a variety of non-self, self and quasi-self damage signals (or ‘garbage’) and activate the innate immune system.” https://www.nature.com/articles/s41574-018-0059-4 View in LinkedIn

WORN OUT. “Inflammaging is the long-term result of the chronic physiological stimulation of the innate immune system, which can become damaging during ageing — a period of life largely unpredicted by evolution.” https://www.nature.com/articles/s41574-018-0059-4 View in LinkedIn

PATHWAYS. “Several cellular and molecular mechanisms are involved in inflammaging, including cellular senescence, mitochondrial dysfunction, defective autophagy and mitophagy, activation of the inflammasome, dysregulation of the ubiquitin–proteasome system, activation of the DNA damage response and dysbiosis (changes in the composition of the host microbiota).” https://www.nature.com/articles/s41574-018-0059-4 View in LinkedIn

CELLULAR CORE. “This chronic, sterile (occurring in the absence of infection and primarily driven by endogenous signals), low-grade inflammation that occurs during ageing is called inflammaging. A major characteristic of inflammaging is the chronic activation of the innate immune system, in which the macrophage has a central role.” https://www.nature.com/articles/s41574-018-0059-4 View in LinkedIn