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CONSERVED MECHANISM. “According to geroscience, inflammation is one of the seven evolutionarily conserved mechanistic pillars of ageing that are shared by age-related diseases, including metabolic diseases.” https://www.nature.com/articles/s41574-018-0059-4 View in LinkedIn

BIOMARKERS OF AGEING. “Finally, we propose the use of new biomarkers (DNA methylation, glycomics, metabolomics and lipidomics) that are capable of assessing biological versus chronological age in metabolic diseases.” https://www.nature.com/articles/s41574-018-0059-4 View in LinkedIn

FASTER AGEING. “We argue that chronic diseases are not only the result of ageing and inflammaging; these diseases also accelerate the ageing process and can be considered a manifestation of accelerated ageing.” https://www.nature.com/articles/s41574-018-0059-4 View in LinkedIn

THE MICROBIOME. “The gut microbiota has a central role in both metaflammation and inflammaging owing to its ability to release inflammatory products, contribute to circadian rhythms and crosstalk with other organs and systems.” https://www.nature.com/articles/s41574-018-0059-4 View in LinkedIn

DEGRADATION RECEPTORS. “A limited number of receptors, whose degeneracy allows them to recognize many signals and to activate the innate immune responses, sense these stimuli. In this situation, metaflammation (the metabolic inflammation accompanying metabolic diseases) is thought to be the form of chronic inflammation that is driven by nutrient excess or overnutrition; metaflammation is characterized by the same mechanisms underpinning inflammaging.” https://www.nature.com/articles/s41574-018-0059-4 View in LinkedIn

DEGRADING SYSTEMS. “From an evolutionary perspective, a variety of stimuli sustain inflammaging, including pathogens (non-self), endogenous cell debris and misplaced molecules (self) and nutrients and gut microbiota (quasi-self).” https://www.nature.com/articles/s41574-018-0059-4 View in LinkedIn

AGEING AND INFLAMMATION. “Ageing and age-related diseases share some basic mechanistic pillars that largely converge on inflammation. During ageing, chronic, sterile, low-grade inflammation — called inflammaging — develops, which contributes to the pathogenesis of age-related diseases. “ https://www.nature.com/articles/s41574-018-0059-4 View in LinkedIn

CO-EVOLUTION. “Accordingly, food sources, metabolism, endocrine responses, innate immune responses and inflammation co-evolved, and the macrophage is a master cell at the interface between metabolism and immunity. Several lines of evidence suggest that the immune, metabolic and endocrine responses co-evolved.” https://www.nature.com/articles/s41574-018-0059-4 View in LinkedIn

ORIGIN OF ANTIMATTER. “(2) Secondary antimatter. It is formed as a result of the collision of the nuclear component of cosmic rays with interstellar gas or with a supernova shell.” https://lnkd.in/gDYri97U View in LinkedIn

AGE-RELATED DISEASE. “The new geroscience field offers a new perspective to address the increasing incidence of chronic age-related diseases, including metabolic disorders such as the metabolic syndrome, obesity, type 2 diabetes mellitus (T2DM) and cardiovascular diseases. The increasing incidence of these pathologies is a reflection of the growing ageing population observed worldwide.” https://www.nature.com/articles/s41574-018-0059-4 View in LinkedIn