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THE MECHANISMS. “The great novelty is that experimental data have emerged that suggest that there are few pillars (adaptation to stress, epigenetics, inflammation, macromolecular damage, metabolism, proteostasis, stem cells and regeneration).” https://www.nature.com/articles/s41574-018-0059-4 View in LinkedIn

AGEING = DISEASE. “The basic assumption of geroscience is that the mechanisms driving ageing and age-related diseases largely overlap, and seven common ‘pillars’ (which are mechanisms of ageing and major areas of research) have been identified.” https://www.nature.com/articles/s41574-018-0059-4 View in LinkedIn

ORIGIN OF ANTIMATTER. “(2) Secondary antimatter. It is formed as a result of the collision of the nuclear component of cosmic rays with interstellar gas or with a supernova shell.” https://lnkd.in/gDYri97U View in LinkedIn

AGE-RELATED DISEASE. “The new geroscience field offers a new perspective to address the increasing incidence of chronic age-related diseases, including metabolic disorders such as the metabolic syndrome, obesity, type 2 diabetes mellitus (T2DM) and cardiovascular diseases. The increasing incidence of these pathologies is a reflection of the growing ageing population observed worldwide.” https://www.nature.com/articles/s41574-018-0059-4 View in LinkedIn

ORIGIN OF ANTIMATTER. “According to the modern concepts it has three possible nature of origin: (1) Primordial antimatter. It could be created in the early Universe as the reflection of nonhomogeneous baryosynthesis, evolve in antimatter domains and now it can exist in the form of macroscopic antimatter objects like globular clusters of antimatter stars.” https://lnkd.in/gDYri97U View in LinkedIn

“BIOMARKERS of biological age, such as DNA methylation, glycomics, metabolomics and lipidomics, can be successfully applied to metabolic diseases.” https://www.nature.com/articles/s41574-018-0059-4 View in LinkedIn

DIAGNOSTIC. “Antimatter is detected in cosmic rays.” https://lnkd.in/gDYri97U View in LinkedIn

INTERACTING SYSTEMS. “The gut microbiota has a central role in metaflammation and inflammaging, as it can release inflammatory products and contribute to the circadian rhythms and crosstalk with other organs and systems.” https://www.nature.com/articles/s41574-018-0059-4 View in LinkedIn

THE FIRST PREDICTION. “At the end of the 1920s, Paul Dirac predicted the existence of antiparticles — that is new particles, which are opposite in sign of electric, baryonic, lepton and other charges of already known particles.” https://lnkd.in/gDYri97U View in LinkedIn

NUTRIENT EXCESS. “Inflammaging and metaflammation largely share the same molecular mechanisms, in which metaflammation can be conceptualized as a specific situation of chronic inflammation caused by nutrient excess.” https://www.nature.com/articles/s41574-018-0059-4 View in LinkedIn