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NUTRIENT EXCESS. “Inflammaging and metaflammation largely share the same molecular mechanisms, in which metaflammation can be conceptualized as a specific situation of chronic inflammation caused by nutrient excess.” https://www.nature.com/articles/s41574-018-0059-4 View in LinkedIn

TESTING. “We test the hypothesis of the existence of an old globular cluster of anti-stars in the galactic halo by evaluating the flux of helium anti-nuclei in galactic cosmic rays.” https://lnkd.in/gDYri97U View in LinkedIn

A beautiful fish at the fish market. As someone with a saltwater tank, it is increasingly difficult to eat fish. View in LinkedIn

ELECTRONIC TRIGGER. “When a photon hits a visual pigment, the chromophore changes from a 11-cis-retinal conformation to an all-trans-retinal, initiating the phototransduction cascade that leads to vision.” The nerve impulses then get chunked and reassembled by the brain into a cartoonized reality. https://lnkd.in/dsvuECMN View in LinkedIn

SO ENDS this summary of the components of inflammation that contribute to both ageing and the chronic diseases of ageing. One can argue that trees drop their leaves in the autumn because they have accumulated considerable environmental and parasitic damage during the active summer period, and it is less difficult to start over and make a new leaf than to fix the numerous sites of cellular damage. https://www.nature.com/articles/s41574-018-0059-4 View in LinkedIn

PATHWAYS. “Several cellular and molecular mechanisms are involved in inflammaging, including cellular senescence, mitochondrial dysfunction, defective autophagy and mitophagy, activation of the inflammasome, dysregulation of the ubiquitin–proteasome system, activation of the DNA damage response and dysbiosis (changes in the composition of the host microbiota).” https://www.nature.com/articles/s41574-018-0059-4 View in LinkedIn

CELLULAR CORE. “This chronic, sterile (occurring in the absence of infection and primarily driven by endogenous signals), low-grade inflammation that occurs during ageing is called inflammaging. A major characteristic of inflammaging is the chronic activation of the innate immune system, in which the macrophage has a central role.” https://www.nature.com/articles/s41574-018-0059-4 View in LinkedIn

THE ROOF COLLAPSES. “Interestingly, the tightly networked ageing pillars converge on inflammation, as impairment of any one pillar fuels inflammation, which subsequently affects all the other pillars.” https://www.nature.com/articles/s41574-018-0059-4 View in LinkedIn

UNEXPLAINED. “Primordial antimatter. The baryon asymmetry of the Universe is the observed predominance of matter over antimatter in the visible part of the Universe.” https://lnkd.in/gDYri97U View in LinkedIn

“DARK MATTER makes up ∼ 85% of all matter in the universe. Its presence is implied in many astrophysical and astrological observations, including gravitational effects and large-scale structure formation.” https://lnkd.in/gDYri97U View in LinkedIn