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PICTORIAL of inflammation-related diseases and the pathways of activation of inflammation. https://lnkd.in/ehvCn2w View in LinkedIn

"MICRO-RNAs are evolutionarily conserved small non-coding RNAs consisting of on average 22 nucleotides. They mediate post-transcriptional changes in gene expression usually through binding to the 3′ untranslated region (3′UTR) of target mRNAs with their seed region." https://lnkd.in/erkHGt5 View in LinkedIn

HUGE DISEASE ROLE. "It was initially thought that the inflammasomes participated only in pathogen recognition and in the pathogenesis of a few, rare, hereditary inflammatory disorders. On the contrary, it is now clear that they have a central role in the pathogenesis of basically all types of chronic inflammation, in metabolic diseases and cancer." https://lnkd.in/eNNPn5D View in LinkedIn

GLOBAL GENETIC MARKETPLACE. "Our bodies are a global marketplace where bacteria trade genes. For example, the gut bacteria of Japanese people have a gene that helps them to digest seaweed. They borrowed it from an oceanic species that hitched its way into Japanese bowels, aboard uncooked pieces of sushi." https://lnkd.in/etuiYJg View in LinkedIn

CHRONIC INFLAMMATION. "Patterns of local immune activation due to temporary loss of barrier function, pathogen invasion, or release of endogenous mediators, followed by tissue destruction and functional impairment characterize many chronic human disease conditions. The cellular and molecular profiles of immune activation in chronic inflammatory disorders overlap considerably with those patterns observed in effective, self-limited host responses to microbial pathogens and involve similar initiating mechanisms." http://www.sciencedirect.com/science/article/pii/S0092867406001917 View in LinkedIn

GENE UPTAKE FROM FOOD. "Dogmas concerning absence of hazards have often been proven wrong (e.g. the Titanic). A relevant example is the belief that DNA in food and forage cannot be taken up from the gastrointestinal tract. This belief was supported by some experimental studies, and the whole evolutionary history as well as our daily intake of vast amounts of DNA from various sources goes to prove it." Or, you are what you eat? https://lnkd.in/eJ8cwgX View in LinkedIn

THE IMMENSE CHALLENGE. "The total number of microbes (∼10(14)) normally inhabiting our mucosal surfaces exceeds by an order of magnitude the quantity of cells (∼10(23)) in our bodies. Scattered amidst these commensal microflora are potential pathogens—viruses, bacteria, or parasites, intrinsically capable of producing symptomatic infectious disease." http://www.sciencedirect.com/science/article/pii/S0092867406001917 View in LinkedIn

UNKNOWN. "Prior to this year, governments concluded that transfer of DNA from GM crops/foods is unlikely to occur. Now we can see that they are wrong, or perhaps they had knowledge of this already? Regardless of the fact that DNA from GM foods can be transferred to humans and animals, very little is still known today and what is known does not look good." https://lnkd.in/ez2_YTV View in LinkedIn

TOXIC REACTIVE OXYGEN. "Extracellular ATP and the P2X7R are also important in inflammasome activation as triggers of ROS generation. Many agents reported to drive NLRP3 activation via ROS generation are also potent triggers of ATP release (Aβ, hyperglycemia, skin irritants, infections, ultraviolet light)." (ROS = toxic reactive oxygen species from mitochondria). https://lnkd.in/eNNPn5D View in LinkedIn

REFUTED RESULTS of food to blood study published in 2015. https://lnkd.in/eZfneK2 View in LinkedIn