linkedin post 2020-02-28 04:51:36

linkedin post 2020-02-28 04:51:36

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NO LONGER LUNATIC FRINGE. "Radical life extension isn’t consigned to the realm of cranks and science fiction writers any more,” says David Masci, a researcher at the Pew Research Centre, who recently wrote a report on the topic looking at the scientific and ethical dimensions of radical life extension. “Serious people are doing research in this area and serious thinkers are thinking about this." https://www.theguardian.com/science/2015/jan/11/-sp-live-forever-extend-life-calico-google-longevity View in LinkedIn
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linkedin post 2020-02-28 04:54:47

linkedin post 2020-02-28 04:54:47

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RESVERATROL. "After Sirtris, a company co-founded by Sinclair, showed that resveratrol-inspired compounds had favourable effects in mice, it was bought by drug giant GlaxoSmithKline for $720m in 2008. Although development has proved more complicated than first thought, GSK is planning a large clinical trial this year." https://www.theguardian.com/science/2015/jan/11/-sp-live-forever-extend-life-calico-google-longevity View in LinkedIn
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linkedin post 2020-02-28 04:58:49

linkedin post 2020-02-28 04:58:49

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PHARMETERNITY. "James Kirkland, a researcher who studies ageing at the Mayo Clinic, says he knows of about 20 drugs now – more than six of which had been written up in scientific journals – that extended the lifespan or healthspan of mice." https://www.theguardian.com/science/2015/jan/11/-sp-live-forever-extend-life-calico-google-longevity View in LinkedIn
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linkedin post 2020-02-29 05:32:28

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FRAGMENT FROM NATURE covers the topic of finding the function of genes. Structure, it turns out, is not enough to denote function. Context and interactions are what determine function. Interactions between gene products, and later post-translational modifications can amplify and determine functionality. The picture is far more complex than sequence alone. It is in this meta sense that diversity arises from a relatively limited hand of cards. View in LinkedIn
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linkedin post 2020-02-29 05:34:50

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IST SIGNPOST. “Consider the quintessential experiment in the founding of molecular biology, the one gene one enzyme hypothesis of Beadle and Tatum. This experiment first connected the genotype directly to the phenotype on a molecular level, although efforts in that direction can certainly be found in the work of Archibald Garrod, Sewell Wright, and others.” https://lnkd.in/dwxby67 View in LinkedIn
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linkedin post 2020-02-29 05:36:23

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ONE GENE, ONE ENZYME. “Here a protein (in this case an enzyme) is seen to be a product of a single gene, and a single function; the completion of a specific step in amino acid biosynthesis is the direct result. It took the next 30 years to fill in the gaps in this process.” https://lnkd.in/dwxby67 View in LinkedIn
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linkedin post 2020-02-29 05:38:21

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THIRTY YEARS LATER. “Yet the one gene one enzyme hypothesis looks very different to us today. What is the function of tubulin, of PI-3 kinase or of rac? Could we accurately predict the phenotype of a nonlethal mutation in these genes in a multicellular organism?” https://lnkd.in/dwxby67 View in LinkedIn
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linkedin post 2020-02-29 05:39:22

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FUNCTION BY CONTEXT. “Although we can connect structure to the gene, we can no longer infer its larger purpose in the cell or in the organism. There are too many purposes; what the protein does is defined by context. The context also includes a history, either developmental or physiological.” https://lnkd.in/dwxby67 View in LinkedIn
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