Month: September 2022

DAO DEFICIENCY SYMPTOMS. "Migraine and other vascular headaches. Gastrointestinal disorders, especially those associated with irritable bowel syndrome, such as constipation, diarrhea, satiety, flatulence or swollen feeling. Dermatological disorders such as dry skin, atopy or psoriasis. Soft-tissue pains usually diagnosed as fibromyalgia. Chronic fatigue." https://lnkd.in/e7VaYYg View in LinkedIn

COMMON DEFICIENCY. "About 25% of the population have DAO enzyme defects that stop histamine degradation, causing symptoms that include migraine." https://lnkd.in/eV-55VH View in LinkedIn

MIGRAINE PREVENTION WITH DAO SUPPLEMENTS. "In one study, 87% of migraine sufferers had defects of their DAO enzyme. "Diamine oxidase supplementation has shown a significant reduction in crisis duration and a tendency toward a reduction in number of crises. The treatment is [safe] because we don't have any adverse events." https://lnkd.in/eV-55VH View in LinkedIn

DAO DEFICIENCY TREATMENT with food avoidance, DAO enzyme supplements, vitamin C and vitamin B6. https://lnkd.in/eeqESv9 View in LinkedIn

NEW DRUG TARGETS. "The principal free D-amino acids found in significant amount in animal tissues are D-Ala, D-serine (D-Ser), and D-aspartate (D-Asp). In particular, D-Ser was detected predominantly in the mammalian brain...the human brain contains endogenous D-Ser and D-Asp, which are likely to act as modulators of neurotransmission." https://lnkd.in/eVWBM_B View in LinkedIn

"D-SER behaves as a “neuromodulator” acting as an agonist at the glycine site of NMDA receptors in the mammalian nervous system. L-glutamate (L-Glu) is the main excitatory neurotransmitter in the CNS, where it is involved in the modulation of many physiological processes, such as learning, memory, and synaptic plasticity." https://lnkd.in/eVWBM_B View in LinkedIn

TOXIN. "A massive influx of L-Glu into the synapses can lead to acute and chronic neurodegenerative diseases (for example, cerebral ischemia, traumatic brain injury, stroke, spinal injury, epilepsy, and Parkinson’s, Alzheimer’s, and Huntington’s diseases)." https://lnkd.in/eVWBM_B View in LinkedIn

LOCKED CHIRALITY. "Protein amino acids are left handed (L-forms) but sugars that make up the DNA backbone are right handed (D-form) in all living things." Mostly. https://lnkd.in/eewE5fQ View in LinkedIn

NATURE DEFIES CHEMISTRY. "While any chiral molecules synthesized in laboratories are always made in racemic (equal proportions of both enantiomers) mixtures, the active organic molecules in all living things are found to always comprise of one enantiomers of a chiral pair." https://lnkd.in/epR5BZe View in LinkedIn

HOMOCHIRALITY. "A recent study has shown that, of the 187,941,074 recorded amino acid sites in the proteome, a mere 837 (that is, 4.5 per 1 million sites) are D-isomers. In light of such statistics it is clear that homochirality is a signature of life as we know it, and natural questions arise regarding its origins." https://lnkd.in/eXz2e82 View in LinkedIn