Category: Uncategorized

CONTROLLING ADVERSE EFFECTS. “Transposable elements are powerful facilitators of evolution but may at the same time be harmful to the individual organism. Therefore, several complementary mechanisms to control transposable element activity have evolved. In many fungi, duplicated DNA is actively mutated by a process called repeat-induced point mutation.” https://lnkd.in/eC8eb-V View in LinkedIn

TWO SIDES OF THE COIN. “Due to the deleterious effect of most genomic rearrangements, the detection and repair of double-strand DNA breaks are tightly regulated. Not surprisingly, mutations affecting central components of double-strand DNA break repair pathways are responsible for an increase in genomic rearrangements.” https://lnkd.in/eC8eb-V View in LinkedIn

INDUCED CODE VARIETY. “Repair of double-strand DNA breaks play important roles in fostering genomic diversity during meiotic and mitotic recombination, and errors during these processes can promote extensive genomic rearrangements.” https://lnkd.in/eC8eb-V View in LinkedIn

DIVERSE MECHANISMS. “In addition to rare, hidden, cycles of sexual reproduction that involve two opposite mating types, non-conventional modes of reproduction are also observed in presumed asexual species.” https://lnkd.in/eC8eb-V View in LinkedIn

USEFUL SUBSTRATES. “The high abundance and their high levels of similarity make transposable elements and other repetitive sequences obvious ectopic substrates in naturally occurring double-strand DNA break repair pathways. Moreover, increasing evidence suggests mobilization of transposable elements by environmental stresses leading to genome evolution.” https://lnkd.in/eC8eb-V View in LinkedIn

OPPOSING LYTIC INFECTION. "Even ‘defective’ (and parasitic) components of viruses (and transposons) can express virus-specific regulatory (opposing) molecules (including ncRNA), clearly promote virus–host persistence, and respond to oppose lytic virus infection." https://lnkd.in/etdQ9rN View in LinkedIn

VIRAL DRIVER. "I am asserting that most initial genetic and selective events that transform host regulatory complexity are usually ‘pushed’ by virus action in a general direction of increasing complexity. In this way, viruses present an omnipresent and ancient issue." https://lnkd.in/etdQ9rN View in LinkedIn

PERFECT EVOLUTIONARY SUBSTRATE. "Viruses possess all the advantages of evolution relative to host: extreme genetic adaptability, extreme diversity, extreme numbers, extreme rates of genetic exchange, tolerance for ‘unfit’ variation, and the ability to reassemble from cryptic or ‘dead’ parts. They can transition between the chemical and living world." http://onlinelibrary.wiley.com/doi/10.1111/apm.12485/full View in LinkedIn

VIRAL EDITORS OF HOST SYSTEMS. "The concept is that viruses are fully competent agents and editors of all host systems of instruction (DNA, RNA, epigenetic, translational etc.). Thus, they provide the host with new sources of instruction systems (not errors). In addition, they promote network formation by providing coherent societies (quasispecies populations) of agents able to edit host code content (and add new identity) in a diffuse, distributed manner, which promotes the creation of and editing of host regulatory networks." http://onlinelibrary.wiley.com/doi/10.1111/apm.12485/full View in LinkedIn

VIRAL TOOLKIT. "These viral colonizers then can also be used to provide new sources of host complexity (such as the placenta)." https://lnkd.in/etdQ9rN View in LinkedIn