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TRAVELING PROTEIN. “Recently, it has been discovered that tau can be released from neurons and taken up by the next neuron. Alpha synuclein can also be transmitted out of a neuron in vesicles, enter another cell, and then when inside the cell break out of the vesicle disrupting the mitochondria.” https://lnkd.in/dKV3Xez View in LinkedIn

PRION-LIKE DISEASES. “Five critical molecules have been studied in this regard—amyloid and tau in Alzheimer’s, alpha-synuclein in Parkinson’s, SOD1 in ALS, and polyglutamine in Huntington’s. Just like PrP each have normal functions in the brain and, then, when misfolded, become prions. It appears that amyloid beta, tau and alph-synuclein influence each other in Alzheimer’s and Parkinson’s.” https://lnkd.in/dKV3Xez View in LinkedIn

PRIONS AND PLANT MEMORY. “Prions, we think, are responsible for some really broad, really interesting biology,” says Lindquist. “We have only seen the tip of the iceberg so far.” https://lnkd.in/df5fVEw View in LinkedIn

FAMILY OF PROTEINS. “Several other protein molecules are now suspected to be prions. These are critical molecules in the major degenerative diseases of the nervous system.” https://lnkd.in/dKV3Xez View in LinkedIn

SMART PRIONS. “Prions are an even simpler infectious agent. While there is much less known about them than viruses, they also engage in complex behavior—exiting and entering of cells, foiling the immune system, multiplying and transporting themselves with immune cells or along neuron circuits and recruiting other proteins to form large structures.” https://lnkd.in/dKV3Xez View in LinkedIn

SPECTRUM" “There are different strains of misfolded prion proteins and not all of them are pathogenic.” https://lnkd.in/d-XFfmf View in LinkedIn

SMART VIRUSES. “A virus will perform a sequence of a dozen coordinated complex actions, each involving seeming intelligence. An example is the herpes virus—enters skin cell, fools nuclear pore, creates DNA machinery to reproduce, leaves cell to enter neuron, hijacks complex transport system, fools new nuclear pore, changes behavior to be quienscent, re activates, and again hijacks the transport system.” https://lnkd.in/dKV3Xez View in LinkedIn

EVIDENCE. “There is now increasing evidence that the clumping of proteins with prion like behavior is a more general phenomenon and important proteins that are involved in many of the major brain diseases have prion like behavior—Alzheimer’s, Parkinson’s, Huntington’s, and ALS.” https://lnkd.in/dKV3Xez View in LinkedIn

INITIATOR. “There are many connections between PrP, and the critical proteins amyloid beta, tau, and alpha-synuclein. Prions appear to serve as a receptor for amyloid beta to start plaques.” https://lnkd.in/dKV3Xez View in LinkedIn

FAMILY OF DISEASES. “Prion-like behavior is a more general phenomenon and important proteins that are involved in many of the major brain diseases have prion like behavior—Alzheimer’s, Parkinson’s, Huntington’s, and ALS.” https://lnkd.in/dKV3Xez View in LinkedIn