linkedin post 2019-12-22 07:04:38

linkedin post 2019-12-22 07:04:38

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CONSERVED EXONS. "Interestingly, tissue-regulated exons associated with the highest rates of disordered amino acids also tended to be the most highly conserved. For example, 63% of the 101 most disordered human brain, skeletal, and or heart-differentially spliced exons are also alternatively spliced in mouse, whereas only 31% of the least disordered 81 exons differentially spliced in these tissues were detected as alternatively spliced exons." http://www.sciencedirect.com/science/article/pii/S1097276512004820 View in LinkedIn
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linkedin post 2019-12-22 07:02:43

linkedin post 2019-12-22 07:02:43

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DISORDER AND INTERACTIONS. "We systematically investigate properties of tissue-regulated alternative exons. We find that proteins containing these coding exons tend to have more interactions in PPI networks. Moreover, these exons, together with the flanking constitutive exons, are enriched in sequences predicted to be highly disordered." (PPI = protein-protein interactions). http://www.sciencedirect.com/science/article/pii/S1097276512004820 View in LinkedIn
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linkedin post 2019-12-22 07:00:25

linkedin post 2019-12-22 07:00:25

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ALTERNATIVE EXONS. "In contrast, differentially regulated alternative exons have not been examined for common functional features. This is an important issue to address, since these exons are generally conserved and maintain frame. Moreover, because they comprise only 10%–30% of total alternative exons, they may possess important functional features that have been overlooked." http://www.sciencedirect.com/science/article/pii/S1097276512004820 View in LinkedIn
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linkedin post 2019-12-22 06:59:09

linkedin post 2019-12-22 06:59:09

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DISORDERED SEQUENCES. "Since disordered regions are highly enriched in ligand binding surfaces and posttranslational modification, this suggests that AS may frequently modulate protein-protein and other ligand interactions." (AS = alternative splicing). http://www.sciencedirect.com/science/article/pii/S1097276512004820 View in LinkedIn
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linkedin post 2019-12-22 06:58:12

linkedin post 2019-12-22 06:58:12

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TERTIARY STRUCTURE. "Analysis of splicing and protein tertiary structure has suggested that alternative exons can have diverse effects on protein folding and function but are also found on the surfaces, within loops or in predicted disordered regions of proteins." http://www.sciencedirect.com/science/article/pii/S1097276512004820 View in LinkedIn
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linkedin post 2019-12-22 06:55:15

linkedin post 2019-12-22 06:55:15

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EXON SUBSETS. "Specific subsets of alternative exons, or “exon networks,” display coordinated regulation between different cell types or conditions. Such exons are often evolutionarily conserved and enriched in genes with related functions, implying that they are involved in important processes or pathway-specific activities. To date, however, the functions of alternative exons within these networks have not been systematically investigated." http://www.sciencedirect.com/science/article/pii/S1097276512004820 View in LinkedIn
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linkedin post 2019-12-23 06:53:54

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DARK HACKING. “The U.S. military is currently developing a battery-powered exoskeleton, the Tactical Assault Light Operator Suit, to provide superior protection from enemy fire and in-helmet technologies that boost the user's communications ability and vision. In theory, the proposed neural implant would allow the military member operating the suit to more effectively control the armored exoskeleton while deployed in combat.” https://lnkd.in/drS7CEG View in LinkedIn
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linkedin post 2019-12-23 06:50:28

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PIONEER BIOHACKERS. “The explosion in extreme tracking is part of a digital revolution in health care led by the tech visionaries who created Apple, Google, Microsoft and Sun Microsystems. Using the chips, database and algorithms that powered the information revolution of the past few decades, these new billionaires now are attempting to rebuild, regenerate and reprogram the human body.” https://lnkd.in/d-ZFhaD View in LinkedIn
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