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SELECTIVE ADVANTAGE. "The presence of DAO enzymes in single-celled creatures allows them to grow on d-amino acid substrates, via the oxidation to achiral products. The selective advantage of being able to metabolize the d-amino acids made in bacteria has probably directed the evolution DAOs in animals." https://lnkd.in/etGHsGm View in LinkedIn

"D-SER behaves as a “neuromodulator” acting as an agonist at the glycine site of NMDA receptors in the mammalian nervous system. L-glutamate (L-Glu) is the main excitatory neurotransmitter in the CNS, where it is involved in the modulation of many physiological processes, such as learning, memory, and synaptic plasticity." https://lnkd.in/eVWBM_B View in LinkedIn

NEW DRUG TARGETS. "The principal free D-amino acids found in significant amount in animal tissues are D-Ala, D-serine (D-Ser), and D-aspartate (D-Asp). In particular, D-Ser was detected predominantly in the mammalian brain...the human brain contains endogenous D-Ser and D-Asp, which are likely to act as modulators of neurotransmission." https://lnkd.in/eVWBM_B View in LinkedIn

DAO DEFICIENCY TREATMENT with food avoidance, DAO enzyme supplements, vitamin C and vitamin B6. https://lnkd.in/eeqESv9 View in LinkedIn

MIGRAINE PREVENTION WITH DAO SUPPLEMENTS. "In one study, 87% of migraine sufferers had defects of their DAO enzyme. "Diamine oxidase supplementation has shown a significant reduction in crisis duration and a tendency toward a reduction in number of crises. The treatment is [safe] because we don't have any adverse events." https://lnkd.in/eV-55VH View in LinkedIn

COMMON DEFICIENCY. "About 25% of the population have DAO enzyme defects that stop histamine degradation, causing symptoms that include migraine." https://lnkd.in/eV-55VH View in LinkedIn

DAO DEFICIENCY SYMPTOMS. "Migraine and other vascular headaches. Gastrointestinal disorders, especially those associated with irritable bowel syndrome, such as constipation, diarrhea, satiety, flatulence or swollen feeling. Dermatological disorders such as dry skin, atopy or psoriasis. Soft-tissue pains usually diagnosed as fibromyalgia. Chronic fatigue." https://lnkd.in/e7VaYYg View in LinkedIn

QUIXOTIC. "Unlike food allergy, the occurrence of symptoms or adverse effects is not linked to the intake of specific food; not only can it be related to a wide variety of food with different histamine contents, symptoms can also occur even after the ingestion of products with low histamine levels." https://lnkd.in/e7VaYYg View in LinkedIn

DAO DEFICIENCY. "In healthy people, histamine taken with food is degraded quickly by Diamine Oxidase (DAO) enzyme, but people with low functional DAO activity have the risk of suffering histamine intolerance or food histaminosis." https://lnkd.in/e7VaYYg View in LinkedIn

HIGH HISTAMINE TRIGGER FOODS. Fermented foods (cheese, yogurt and buttermilk; processed fermented meats (pepperoni, salami, bologna); fermented vegetables (sauerkraut); Fermented drinks (beer, ale and wine); Some fruits such as tomatoes and cherries, and citrus fruits. https://lnkd.in/eqsvvPT View in LinkedIn