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ASSEMBLY OF THE INFLAMMASOME. "The inflammasomes aggregate to generate supramolecular structures akin to those made by the apoptosome, i.e., wheel-shaped pentameric/heptameric complexes of MW in the 500- to 700-kDa range." https://lnkd.in/eNNPn5D View in LinkedIn

NEW TRANSPOSONS. "Eukaryotes contain numerous transposable or mobile elements capable of parasite-like proliferation in the host genome. All known transposable elements in eukaryotes belong to two types: retrotransposons and DNA transposons. Here we report a previously uncharacterized class of DNA transposons called Polintons that populate genomes of protists, fungi, and animals." (2015). https://lnkd.in/evfenaM View in LinkedIn

STRUCTURALLY SIMILAR. Apoptosome and inflammasome are both multimeric protein complexes that mediate the activation of specific caspases upon the onset of apoptosis and inflammation respectively. The central component of apoptosome or inflammasome is a tripartite scaffold protein. https://lnkd.in/eF74yds View in LinkedIn

MINIMAL CELL CREATED. http://www.nature.com/news/minimal-cell-raises-stakes-in-race-to-harness-synthetic-life-1.19633 View in LinkedIn

THE BEAUTIFUL STRUCTURE of the inflammasome resembles the apoptosome that triggers programmed cell death. Both are circular with distinct segment arms. https://lnkd.in/eSuQQy4 View in LinkedIn

MORE WORK. "But for the survival of any creature whose genes carry them, introns are a problem to solve. Somehow, at some stage, introns have to be removed before the ultimate product of the gene, the protein, can be made without error." https://lnkd.in/e8u5vxc View in LinkedIn

SENSOR AND COORDINATOR. "Inflammasomes are essential components of host defense and they guard the host robustly from the assault of microbial pathogens and endogenous danger signals." https://lnkd.in/edtaHiu View in LinkedIn

MORE WORK. "But for the survival of any creature whose genes carry them, introns are a problem to solve. Somehow, at some stage, introns have to be removed before the ultimate product of the gene, the protein, can be made without error." https://lnkd.in/e8u5vxc View in LinkedIn

CRITICAL FUNCTION. "Inflammasomes play a central role in maintaining the sanctity of the cytosol." https://lnkd.in/edtaHiu View in LinkedIn

TEXTUS INTERRUPTUS. "Introns are interruptions in the text of eukaryotic genes. Every time the genome is replicated, they are replicated right along with it. For Richard Dawkins, introns are an example of pure "selfish DNA," out for its own survival only." https://lnkd.in/e8u5vxc View in LinkedIn