linkedin post 2016-09-26 05:12:42

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LARGE OCCUPANCY. "Due to this degeneracy, estimates of the proportion of the human genome occupied by TEs has varied widely, between one-half and two-thirds. Larger genomes, such as those of salamanders and lungfishes, almost certainly contain an even more enormous quantity of transposable element DNA." (TE = transposable elements). http://journals.plos.org/plosgenetics/article?id=10.1371/journal.pgen.1004351 View in LinkedIn
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linkedin post 2016-09-28 05:28:46

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"PSEUDOGENES are functionless relatives of genes that have lost their gene expression in the cell or their ability to code protein. Pseudogenes often result from the accumulation of multiple mutations within a gene whose product is not required for the survival of the organism. Although not protein-coding, the DNA of pseudogenes may be functional, similar to other kinds of noncoding DNA which can have a regulatory role." https://lnkd.in/euq3niU View in LinkedIn
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linkedin post 2016-09-28 05:23:04

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ROLES IN TIME AND SPACE. "Greater than 95% of human multi-exon genes express multiple splice isoforms. Furthermore, there is evidence for alternatively splicing events that are often differentially regulated across tissues and during development, as well as among individuals and populations, suggesting that individual isoforms may serve specific spatial or temporal roles." http://bitesizebio.com/10148/what-is-alternative-splicing-and-why-is-it-important/ View in LinkedIn
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linkedin post 2016-09-26 05:01:36

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ANCIENT VIRAL BITS AND PIECES. "By far the dominant type of nongenic DNA are transposable elements (TEs), including various well-described retroelements such as Short and Long Interspersed Nuclear Elements (SINEs and LINEs), endogenous retroviruses, and cut-and-paste DNA transposons." http://journals.plos.org/plosgenetics/article?id=10.1371/journal.pgen.1004351 View in LinkedIn
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linkedin post 2016-09-28 05:20:09

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MAJORITY OF GENES ALTERNATIVELY SPLICE. "At least 75% of roughly 30,000 human genes undergo alternative splicing to encode two or more splice isoforms, with striking variation across tissue types and developmental stages." http://bitesizebio.com/10148/what-is-alternative-splicing-and-why-is-it-important/ View in LinkedIn
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linkedin post 2016-09-27 05:50:56

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ALTERNATIVE SPLICING "is a process by which exons or portions of exons or noncoding regions within a pre-mRNA transcript are differentially joined or skipped, resulting in multiple protein isoforms being encoded by a single gene. This mechanism increases the informational diversity and functional capacity of a gene during post-transcriptional processing and provides an opportunity for gene regulation." http://bitesizebio.com/10148/what-is-alternative-splicing-and-why-is-it-important/ View in LinkedIn
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