TIMING PACEMAKER. “Collectively these findings implicate a critical signaling axis that coordinates the central pacemaker with peripheral circadian transcription and metabolism, though the implications of these findings in humans remains unresolved (Box 2).”
https://www.nature.com/articles/s41591-018-0271-8?fbclid=IwAR01C2Z4J5lxVYDLhxIb9dPb3fhNSZSxwimZvhHaJ4n3-nVPpkt2PNqoukk