Category: Uncategorized

EVOLUTIVE CHEMISTRY. “The combination of the features of supramolecular systems—information and programmability, dynamics and reversibility, constitution and diversity—leads toward the emergence of adaptive/evolutive chemistry. It is, by essence, of supramolecular nature because it is determined by interaction with an external entity. It may be constitutional and/or morphological (as occurs in “induced fit” for instance). Adaptive chemistry implies selection and growth under time reversibility.” https://lnkd.in/dN969hA View in LinkedIn

“SELF-ORGANIZATION BY SELECTION requires dynamic diversity (constitutional and/or morphological) on which to operate. This is made possible by the implementation of CDC responding to the pressure of either internal or external factors. Selection has an implicit information content. It is also truly a supramolecular process, because it occurs in relation to interactions with surroundings (which may be either the medium or a more or less distant part of a folded macromolecule).” https://lnkd.in/dN969hA View in LinkedIn

“SELF-ORGANIZATION BY DESIGN has been pursued with the goal to achieve full control over the output supramolecular entity by means of correctly instructed components, specific interaction algorithms, and (as much as possible) strict programming. Design is knowledge-based and has an explicit information content.” https://lnkd.in/dN969hA View in LinkedIn

MOLECULAR EVOLUTION. “Whereas preorganization relies entirely on design, supramolecular self-organization introduces in addition the possibility to let the system build up by selection.” https://lnkd.in/dN969hA View in LinkedIn

MOLECULAR COMPUTATION. “The combination of different recognition/instruction features in a molecular program opens a door to the design of self-organizing systems capable of performing molecular computation. Computing by self-assembly may yield a powerful alternative to conventional models. Recent studies described the use of biomolecules and DNA-based protocols to solve computational problems.” https://lnkd.in/dN969hA View in LinkedIn

OUTPUT IMPLICATIONS. “The processing of the same ligand information by different interaction algorithms (e.g., through the use of different sets of metal ions or of different H-bonding effectors) allows the controlled self-organization of different output architectures, resulting in multiple expression of molecular information, through postinformational (postgenomic!) operations. Such a one code/several outputs scheme, in addition to the one code/one output (product) mode, also has in principle significant implications in biology.” https://lnkd.in/dtRiQxQ View in LinkedIn

TOWARDS MULTIPLE-CODING. “The generation of a given superstructure through self-organization results, in its simplest form, from the operation of a single-code assembly program. A step beyond consists in devising systems of higher complexity that operate in multimode fashion through the implementation of several codes within the same overall program, resulting in multiple self-organization processes.” https://lnkd.in/dN969hA View in LinkedIn

LIQUID CRYSTAL ASSEMBLY. ““Discotic liquid crystals form by the assembly of “sector”-shaped components into disks, which thereafter organize into columns, and template binding by molecular strands induces wrapping into helical disk-like objects, which then aggregate into large supramolecular assemblies.” https://lnkd.in/dN969hA View in LinkedIn

DEEP MINING. “The resulting map is mined for relationships between training dataset enrichments in specific units and can be interpreted further by laying additional data on the map not used during the training. These maps typically reveal very distinct colocalization patterns between particular datasets in specific cell-types.” https://bmcsystbiol.biomedcentral.com/articles/10.1186/1752-0509-8-S2-S1 View in LinkedIn

GLOBAL ASSESSMENTS. “A hallmark of this functional data is that they represent global measurements of thousands of molecular features where no one feature has an a priori higher importance than others.” https://bmcsystbiol.biomedcentral.com/articles/10.1186/1752-0509-8-S2-S1 View in LinkedIn