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COMPLEXITY FLUX. “If the complexity is not stationary it will either increase or decrease. If it increases it will continue to increase, but if it decreases that will not last long. It will reach a minimum and turn around.” https://onlinelibrary.wiley.com/doi/full/10.1002/prop.201500092?casa_token=8OO3b1OY4e4AAAAA%3ARqriAgTwtxnvsxl09CqnNy79m7l4ye7ZrkZxcLtObB9kHsTwYgzBuIV2X-xXQ7ezoR6VQPfQLCS-vnI View in LinkedIn

THE DATA. “The amount of H2O consumed by the control group from either of the two bottles, both containing H2O, is depicted in Fig. 3c. Overall, the data shows that in all three experiments mice consumed comparable amounts of H2O and D2O, with significant increase of consumption of the sucrose solution.” https://lnkd.in/dzPDm5w View in LinkedIn

SWEET PREFERENCE. “By contrast, mice exhibit a strong preference for sucrose solution over H2O. Indeed, the consumed volume was significantly increased in line with the predilection of mice for sucrose solutions (Fig. 3b).” https://lnkd.in/dzPDm5w View in LinkedIn

FRAGMENT FROM NATURE continues from last weekend and concludes this weekend on a surprising paper showing that heavy water tastes different from normal water; given the subtlety of the difference, it is surprising and speaks to the exquisitely nuanced nature of taste receptors, that not only can they distinguish the small structural difference but can communicate that to the brain. An extraordinarily thorough paper. View in LinkedIn

Traditional Catalan fisherman’s dish makes splendid use of whatever leftovers are at hand. View in LinkedIn

THE LIMIT OF MIND. “The physics of information processing imposes limits on what can be achieved by any civilization.” https://lnkd.in/gSJJ5XA View in LinkedIn

NEUTRON STARS. “Recent theoretical models propose some alternatives, such as inner cores containing a mix of neutrons, protons, and exotic matter made of quarks or new combinations of quarks.” The old impossible is the new probable. https://lnkd.in/dZCjeAB View in LinkedIn

FURTHER VALIDATION. “Next, we carried out microsecond MD simulations of the TMD embedded in a phospatidylcholine (POPC) bilayer in either H2O or D2O (for details including our model of D2O effectively including nuclear quantum effects, (see SI, Tables S2–S4). Note that water molecules enter the TMD domain and cluster at positions that partially overlap with the modeled water positions, see Fig. 7a.” https://lnkd.in/dzPDm5w View in LinkedIn

MOLECULAR VALIDATION. “Fig. 7: Differences between the behavior of the transmembrane part of the human sweet taste receptor in H2O vs D2O base on analysis of three independent microsecond trajectories.” https://lnkd.in/dzPDm5w View in LinkedIn

“FUTURE STUDIES should be able to elucidate the precise sites and mechanisms of action, as well as the reason why D2O activates TAS1R2/TAS1R3 in particular, resulting in sweet (but not other) taste. To this end, site-directed mutagenesis as well as determination of the precise structure of the TAS1R2/TAS1R3 receptor will be of key importance.” https://lnkd.in/dzPDm5w View in LinkedIn