VICTORY LAP. “Indeed, reading Moore, one gets the impression that the lac operon model was a victory of the embryological view over the genetic.” https://lnkd.in/dQuxg6Y View in LinkedIn
EPIGENETICS. “John Moore: Embryologists, he wrote, were adamant that non-genetic phenomena could influence what the identical genes actually do, but the geneticists were set against it. "This point of view, which once would have been reasonable to an embryologist but not to a geneticist, now seems reasonable to both." https://lnkd.in/dQuxg6Y View in LinkedIn
TURNING POINT. “In a 1961 review article, Jacob and Monod emphasize that operon-like control mechanisms may be a universal part of gene regulation.” https://lnkd.in/dQuxg6Y View in LinkedIn
IRREDUCIBILITY. “I have found it difficult to avoid the conclusion that many of the investigators concerned with morphogenesis are secretly convinced that the problem is insoluble. I get the feeling that many of the intricate phenomena described are greeted with a sort of glee as if to say, " My God, this is wonderful, it is so complicated we will never understand it." https://lnkd.in/dQuxg6Y View in LinkedIn
PLASMAGENES. “The cytoplasm is seen to act directly on the genes and not on their intermediate products. After reviewing enzymatic adaptation (and calling it that), Stern claims that there is no convincing evidence for the existence of the postulated plasmagenes.” https://lnkd.in/dQuxg6Y View in LinkedIn
THE NEW ALCHEMY. “According to Lvtrup and colleagues (1978), "few compounds, other than the philosopher's stone, have been searched for more intensely than the presumed agent of primary embryonic induction in the amphibian embryo.” https://lnkd.in/dQuxg6Y View in LinkedIn
SEQUENTIAL INDUCTION. “The exposure of an organism to a single inducer which is also a substrate may result in the induction of a sequence of enzymes, since the metabolism of the primary inducer gives rise to the formation of a succession of intermediary metabolites each of which serves as an inducer for the enzyme which converts it to the next member of the metabolic chain. This phenomenon is termed 'sequential induction' (simultaneous or successive adaptation)." https://lnkd.in/dQuxg6Y View in LinkedIn
THE ROOT OF THE PROBLEM. “Jean Baptiste Lamarck in 1809 proposed his concept that all living things, through the process of evolution, strive for perfection.” https://lnkd.in/da7dRTF View in LinkedIn