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MECHANISM OF ACTION. Domoic acid "is structurally related to kainic acid, which is an analogue to the excitatory amino acid and neurotransmitter L-glutamate." https://lnkd.in/e3pZBba View in LinkedIn

"DOMOIC ACID is two to three times more potent than kainic acid and 30 to 100 times more potent than glutamate" in animal models. https://lnkd.in/ezgTzXm View in LinkedIn

DOMOIC ACID is a (-) levorotatory excitatory amino acid neurotoxin that is an glutamate brain receptor (AMPA/KA and NMDA) agonist, which contains within it the structure of glutamic acid, and is a structural analog of proline and a neurotoxin called kainic acid (also an analog of the excitatory amino acid L-glutamate). All these molecules, domoic acid, kainic acid and glutamate, act on diverse glutamate receptors. View in LinkedIn

D-AMINO ACIDS IN SHELLFISH. "In communities in which marine shellfish represent an important source of food, account should be taken of D-amino acids consumed in large quantities, not only with respect to nutrition, but also from the toxicological aspect...quantities of D-amino acids occurring in marine shellfish can exceed 1%." https://lnkd.in/eNSAN8h View in LinkedIn

RED TIDE. Normally, diatoms are known for their enormous positive impact on global oxygen supply, silica and carbon cycling. https://lnkd.in/ecddBh2 View in LinkedIn

RED TIDE toxicity is surprisingly attributable to a tiny diatom, rather than dinoflagellates or cyanobacteria. This diatom is called Nitzcheria pungens, or now pseudonitzcheria multiseries. This is the largest diatom genus with 900 species. https://lnkd.in/ecddBh2 View in LinkedIn

RED TIDE INDEX CASE. CNS neuronal necrosis was found on post-mortem. Attributed to domoic acid in cultivated mussel beds, confirmed by sampling, and attributed to red algae poisoning (red tide). https://lnkd.in/ezgTzXm View in LinkedIn

RED TIDE INDEX CASE. The 1987 case of shellfish poisoning in Prince Edward Island, Canada was where this story started. Of the 250 reports, 107 met the clinical definition, 19 people were hospitalized, 12 were in intensive care, with 3 deaths. https://lnkd.in/ezgTzXm View in LinkedIn

TOUGH TOXIN. "There is no known antidote available for domoic acid, so if symptoms fit the description, it is advised to go quickly to a hospital. Cooking or freezing affected fish or shellfish tissue does not lessen the toxicity." https://lnkd.in/eysn5Z5 View in LinkedIn

RED TIDE. August 5, 2015: news flash. "This coastal ribbon of microscopic algae, up to 40 miles wide and 650 feet deep in places, is flourishing amid unusually warm Pacific Ocean temperatures." Once quite rare, this is an increasingly common report. https://lnkd.in/eFVnC_b View in LinkedIn