Category: Uncategorized

CLEAVAGE COMPLEXITY. "Not only are there differences in the number and placement of the cleavage sites, but also the recognition sites are relatively diverse, and many retroviral proteins contain sequences that would appear to be suitable sites for cleavage by the corresponding retroviral protease that remain uncleaved." https://lnkd.in/eBisbvi View in LinkedIn

SO ENDS this weekend on the subtle and ever-inventive molecular strategies of viruses and their hosts to act out their age-old relationships that range from benign to symbiotic to pathological. It is a glimpse of evolution's raw ingenuity engine, full of messy experiments that often lead to surprising outcomes. View in LinkedIn

SUGAR HIGH. "We could control influenza infection of mammalian cells by altering the level of glucose given to cells. Higher glucose concentrations induced a dose-specific increase in influenza infection." https://lnkd.in/enM5f-Y View in LinkedIn

APPEARANCE OF THE PLACENTA. "Over 120 million years ago, eutherian mammals appeared on the earth. Their appearance was dependent on the evolution of the placenta, which, by mediating nutrient and gas exchange between mother and fetus, serves the central role in bearing live offspring." https://lnkd.in/eN_bZTg View in LinkedIn

CHAIN REACTION. "One key event in the course of apoptosis is the disruption of mitochondrial membranes. As a result, cellular respiration stops forcing the cells into a compensation strategy to keep energetic status at a sufficiently high level. This results in an increased rate of glycolysis." http://www.biomedcentral.com/1752-0509/4/61 View in LinkedIn

"THE INVENTION OF THE PLACENTA facilitated the evolution of mammals. How the placenta evolved from the simple structure observed in birds and reptiles into the complex organ that sustains human life is one of the great mysteries of evolution." https://lnkd.in/eN_bZTg View in LinkedIn

CELL DEATH IMBALANCE. "We conclude that virus replication itself does not have a major impact on metabolism, but rather the onset of apoptosis causes this metabolic imbalance." http://www.biomedcentral.com/1752-0509/4/61 View in LinkedIn

SECOND GIANT JUMP. "The second involved the incorporation of a large series of retroviral genomes that have contributed to genomic evolution, embryology and adult physiology." http://onlinelibrary.wiley.com/doi/10.1111/apm.12488/full View in LinkedIn

BUILDING IS COSTLY. "The replication of virus requires energy for synthesis of macromolecules like proteins or, depending on the virus, DNA or RNA. Additionally, in the case of an enveloped virus, the budding of viruses forces cells to a de novo synthesis of membrane lipids." https://lnkd.in/eBn_iXD View in LinkedIn

FIRST GIANT JUMP. "The human genome has experienced two distinct rounds of holobiontic evolutionary change. The first of these involved the incorporation of the bacterial symbiont that gave rise to our human mitochondria, enabling us to breathe oxygen." https://lnkd.in/ecEx-Mq View in LinkedIn