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THE BEAUTIFUL STRUCTURE of the inflammasome resembles the apoptosome that triggers programmed cell death. Both are circular with distinct segment arms. https://lnkd.in/eSuQQy4 View in LinkedIn

MORE WORK. "But for the survival of any creature whose genes carry them, introns are a problem to solve. Somehow, at some stage, introns have to be removed before the ultimate product of the gene, the protein, can be made without error." https://lnkd.in/e8u5vxc View in LinkedIn

SENSOR AND COORDINATOR. "Inflammasomes are essential components of host defense and they guard the host robustly from the assault of microbial pathogens and endogenous danger signals." https://lnkd.in/edtaHiu View in LinkedIn

MORE WORK. "But for the survival of any creature whose genes carry them, introns are a problem to solve. Somehow, at some stage, introns have to be removed before the ultimate product of the gene, the protein, can be made without error." https://lnkd.in/e8u5vxc View in LinkedIn

CRITICAL FUNCTION. "Inflammasomes play a central role in maintaining the sanctity of the cytosol." https://lnkd.in/edtaHiu View in LinkedIn

TEXTUS INTERRUPTUS. "Introns are interruptions in the text of eukaryotic genes. Every time the genome is replicated, they are replicated right along with it. For Richard Dawkins, introns are an example of pure "selfish DNA," out for its own survival only." https://lnkd.in/e8u5vxc View in LinkedIn

PRICE OF COMPLEXITY. "Introns are rare within prokaryotic cells. They are rare within the nuclear genomes of single-celled eukaryotes. However, within the cells of multicelled animals and plants almost every gene has introns." https://lnkd.in/e8u5vxc View in LinkedIn

INTRONS. "These are sequences of DNA, within genes, which have no apparent purpose. You could think of introns as long commercials, in a language you don't understand, interrupting your favorite television show right in the middle of the action." https://lnkd.in/e8u5vxc View in LinkedIn

TRANSPOSON CUT-AND-PASTE. "Not only can some TEs copy their own genomes — they can also copy and paste parts or wholes of adjacent human genes. And they can relocate or paste in the DNA where they want, including in the middle of other genes. TEs have played enormously important roles in shaping our evolution and some of these TEs are continuing to do that today." https://lnkd.in/eVPv65H View in LinkedIn

JUMPING GENES. “A transposable element (TE or transposon) is a DNA sequence that can change its position within the genome, sometimes creating or reversing mutations and altering the cell’s genome size." (TEs = jumping genes) https://lnkd.in/eVPv65H View in LinkedIn