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THE LIMIT OF MIND. “The physics of information processing imposes limits on what can be achieved by any civilization.” https://lnkd.in/gSJJ5XA View in LinkedIn

RELATED STUDY. “A step in this direction was undertaken, where a general mechanism – originally proposed for the explanation of an enhanced memory capacity in black holes – was applied to the framework of quantum neural networks and was shown that it leads to an exponential enhancement of pattern storage and recognition capacities.” https://onlinelibrary.wiley.com/doi/full/10.1002/prop.201800007?casa_token=GdPRXs_tGLEAAAAA%3Ag-pxPMtkcleTYDUNK3mYGfpEzKRyc2LqQknTgFFB7dkYFDL8rDe2s0f4_0Q0oKjXD4_AEgFPGWolVTQ View in LinkedIn

ONE PART OF THE ANSWER. “Obviously, the final answer requires the involvement of biology, which is beyond our expertise. However, we can attempt to do a physicist part of the job.” https://onlinelibrary.wiley.com/doi/full/10.1002/prop.201800007?casa_token=GdPRXs_tGLEAAAAA%3Ag-pxPMtkcleTYDUNK3mYGfpEzKRyc2LqQknTgFFB7dkYFDL8rDe2s0f4_0Q0oKjXD4_AEgFPGWolVTQ View in LinkedIn

SIMPLE ORIGINS. “Given that black holes and human brains exhibit extraordinary memory storage capacities, it is natural to ask whether these systems share some very basic mechanism of the enhanced capacity of the information storage.” https://onlinelibrary.wiley.com/doi/full/10.1002/prop.201800007?casa_token=GdPRXs_tGLEAAAAA%3Ag-pxPMtkcleTYDUNK3mYGfpEzKRyc2LqQknTgFFB7dkYFDL8rDe2s0f4_0Q0oKjXD4_AEgFPGWolVTQ View in LinkedIn

THE NEURAL QUANTUM. “The neural network can be described in terms of a quantum field, via identifying the different neurons with the different momentum modes of the field, while identifying the synaptic connections among the neurons with the interactions among the corresponding momentum modes.” https://onlinelibrary.wiley.com/doi/full/10.1002/prop.201800007?casa_token=GdPRXs_tGLEAAAAA%3Ag-pxPMtkcleTYDUNK3mYGfpEzKRyc2LqQknTgFFB7dkYFDL8rDe2s0f4_0Q0oKjXD4_AEgFPGWolVTQ View in LinkedIn

NUCLEAR QUANTUM EFFECT. “At a molecular level, this general behavior may be traced back to the slightly stronger hydrogen bonding in D2O vs H2O, which is due to a nuclear quantum effect, namely difference in zero-point energy. Biologically relevant situations where one may expect strong nuclear quantum effects as implications of H/D substitution directly involve proton or deuteron transfer. Unless a yet unknown indirect mechanism is involved, this is not the case for the TAS1R2/TAS1R3 sweet taste receptor, thus the nuclear quantum effect is probably weak in the present case.” https://lnkd.in/dzPDm5w View in LinkedIn

CELLULAR DOSE RESPONSE. “We further used an IP1 assay on non-transfected HEK 293T cells, where we observed that dose-dependent curves of carbachol—an agonist of the endogenous muscarinic receptor 3 (M3)47—did not show any difference between H2O and D2O-based media (Fig. 6a) and that cell medium that had either 10% or 100% D2O, did not activate basal IP1 accumulation (Fig. 6b).” https://lnkd.in/dzPDm5w View in LinkedIn

MOLECULAR MECHANISM. “Our findings point to the human sweet taste receptor TAS1R2/TAS1R3 as being essential for sweetness of D2O. Molecular dynamics simulations show, in agreement with experiment, that proteins in general are slightly more rigid and compact in D2O than in H2O.” https://lnkd.in/dzPDm5w View in LinkedIn

TITRATION. “The inhibitory effect of lactisole on D2O-activation of the human sweet taste receptor was confirmed using an IP1 assay, while lactisole exposure had no effect on cells treated with pure H2O water, as expected (Fig. 5c). As a control, 960 mM D-glucose elicited increase in IP1 levels in TAS1R2/TAS1R3 expressing cell, which was inhibited in the presence of lactisole.” https://lnkd.in/dzPDm5w View in LinkedIn