linkedin post 2021-05-08 03:41:48

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FURTHER VALIDATION. “Next, we carried out microsecond MD simulations of the TMD embedded in a phospatidylcholine (POPC) bilayer in either H2O or D2O (for details including our model of D2O effectively including nuclear quantum effects, (see SI, Tables S2–S4). Note that water molecules enter the TMD domain and cluster at positions that partially overlap with the modeled water positions, see Fig. 7a.” https://lnkd.in/dzPDm5w View in LinkedIn
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linkedin post 2021-05-09 04:23:16

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“FUTURE STUDIES should be able to elucidate the precise sites and mechanisms of action, as well as the reason why D2O activates TAS1R2/TAS1R3 in particular, resulting in sweet (but not other) taste. To this end, site-directed mutagenesis as well as determination of the precise structure of the TAS1R2/TAS1R3 receptor will be of key importance.” https://lnkd.in/dzPDm5w View in LinkedIn
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linkedin post 2021-05-08 03:39:43

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MOLECULAR DOSE RESPONSE. “Next, TAS1R2/TAS1R3 receptor along with the chimeric Gα16gust44 subunit were transiently expressed, and the functionality was illustrated by dose-dependent response to D-glucose (Fig. 6c). Finally, and in agreement with calcium imaging, we found that 10% D2O activated these cells. Activation by 100% D2O was even more pronounced (Fig. 6d).” https://lnkd.in/dzPDm5w View in LinkedIn
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linkedin post 2021-05-10 04:39:04

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IMPACT OF GRAVITY. “The general message is that for gravity‐like synaptic connections in a quantum neural network the information storage mechanisms can become potentially richer than in more conventional approaches.” https://onlinelibrary.wiley.com/doi/full/10.1002/prop.201800007?casa_token=GdPRXs_tGLEAAAAA%3Ag-pxPMtkcleTYDUNK3mYGfpEzKRyc2LqQknTgFFB7dkYFDL8rDe2s0f4_0Q0oKjXD4_AEgFPGWolVTQ View in LinkedIn
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linkedin post 2021-05-10 04:36:14

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ENHANCED INFORMATION STORAGE. “This state is achieved due to the following effect. A high excitation level of some neurons – due to their negative synaptic connections with others – lowers to zero the excitation threshold energies for the latter neurons, thereby making is possible to store an exponentially large number of patterns within an infinitesimally narrow energy gap. Moreover, the patterns stored in such states can be redialed under an influence of arbitrarily soft external stimuli.” https://lnkd.in/gdGJbxD View in LinkedIn
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linkedin post 2021-05-10 04:33:57

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PHYSICS PLUS BIOLOGY. “The idea is that by allowing the excitatory synaptic connections among the set of neurons to be gravity‐like – in the sense of a negative interaction energy – the network gives rise to a critical state with an exponentially enhanced memory storage capacity.” https://onlinelibrary.wiley.com/doi/full/10.1002/prop.201800007?casa_token=GdPRXs_tGLEAAAAA%3Ag-pxPMtkcleTYDUNK3mYGfpEzKRyc2LqQknTgFFB7dkYFDL8rDe2s0f4_0Q0oKjXD4_AEgFPGWolVTQ View in LinkedIn
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