LIKE GENETICS VS EMBRYOLOGY. “Synthetic biology presents a challenge to traditional accounts of biology: Whereas traditional biology emphasizes the evolvability, variability, and heterogeneity of living organisms, synthetic biology envisions a future of homogeneous, humanly engineered biological systems that may be combined in modular fashion.” https://lnkd.in/dhkrmJx View in LinkedIn
SO ENDS this first of two weekends on the cunning strategy of the bacteria Wolbachia which has enabled it to colonize half of the insect species in the world. The ability of symbionts and parasites to enact sophisticated strategies on their hosts makes one suspect that more than chance is at play, but when nature gambles at such high rates over geological time, even slim probabilities can become realities. It is a game of sheer numbers against the odds of chance. View in LinkedIn
FINE PRINT. “Furthermore, even if the symbiont retained the ability to rescue the cross, for example, if genes are swapped among paralogous pairs within the genome, the pair of genes might be eliminated in the long term if it generated self-incompatibility when transferred to a new genome.” https://lnkd.in/dXjWp9f View in LinkedIn
MOLECULAR EVOLUTION. “A possible molecular cause of this phenomenon comes from the observation that cifA and cifB bind each other, and so binding affinities may be greatest between coevolved genes. If this is the case, then there would be strong selection against recombination between the genes as this could generate symbionts that are unable to rescue crosses with infected females.” https://lnkd.in/dXjWp9f View in LinkedIn
EARLY OBSERVATIONS. “It has long been observed that crosses between insects carrying different Wolbachia strains are frequently incompatible, suggesting that modification and rescue factors must be matched to produce viable offspring.” https://lnkd.in/dXjWp9f View in LinkedIn
MATTER. There is no matter as such. All matter originates and exists only by virtue of a force which brings the particle of an atom to vibration and holds this most minute solar system of the atom together. We must assume behind this force the existence of a conscious and intelligent spirit [orig. geist]. This spirit is the matrix of all matter." (Max Planck) https://en.m.wikipedia.org/wiki/Max_Planck View in LinkedIn
A CLUE. “The entanglement entropy of the black hole is not at all constrained by the Bekenstein-Hawking entropy at late stages of black hole evaporation.” https://lnkd.in/dUKnus8 View in LinkedIn
NEW PARADIGM NEEDED. “In any BH to WH scenario of the type considered in this paper and Paper I the central dogma is clearly false.” (BH = black hole; WH = white hole). https://lnkd.in/dUKnus8 View in LinkedIn
WORMHOLES. “Later in the evaporation process the Hawking partners must correspond to different degrees of freedom than the earlier Hawking partners, and given the finite Hilbert space the Hawking modes with which they are entangled must then be entangled with early Hawking modes, leading to a pure external state when the black hole disappears. This is justified by a very complicated quantum path integral involving "replica wormholes".” https://lnkd.in/dUKnus8 View in LinkedIn